Hemodynamics of Cerebral Aneurysms

作者：Daniel Sforza, Christopher M. Putman, Juan Raul Cebral · 发表于：Annual Review of Fluid Mechanics · 年份：2008 · DOI：10.1146/annurev.fluid.40.111406.102126 · 被引用次数：466 · 研究领域：Intracranial Aneurysms: Treatment and Complications、Intracerebral and Subarachnoid Hemorrhage Research、Moyamoya disease diagnosis and treatment

The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. The combination of abnormal blood patterns and genetics predisposition could lead to the pathological formation of aneurysms. Here, we review recent progress on the basic mechanisms of aneurysm formation and evolution, with a focus on the role of hemodynamic patterns.