Prospective Diagnosis of the Initial Prodrome for Schizophrenia Based on the Structured Interview for Prodromal Syndromes: Preliminary Evidence of Interrater Reliability and Predictive Validity

作者：Tandy J. Miller, Thomas H. McGlashan, Joanna Lifshey Rosen, Lubna Somjee, Philip Markovich, Kelly Stein, Scott W. Woods · 发表于：American Journal of Psychiatry · 年份：2002 · DOI：10.1176/appi.ajp.159.5.863 · 被引用次数：888 · 研究领域：Schizophrenia research and treatment、Mental Health and Psychiatry、Psychopathy, Forensic Psychiatry, Sexual Offending

OBJECTIVE: This study was conducted to determine the interrater reliability and predictive validity of a set of diagnostic criteria for the prodrome of the first episode of schizophrenic psychosis when based on the Structured Interview for Prodromal Syndromes. METHOD: The subjects were patients referred for evaluation because of a suspected schizophrenia prodromal syndrome. For the reliability study, two to four raters independently diagnosed 18 patients on the basis of face-to-face or videotaped interviews. For the validity study, 6- and 12-month outcome data were collected for 29 patients. RESULTS: Agreement in differentiating prodromal from nonprodromal patients was 93%. The prodromal features had converted to schizophrenic psychosis for 46% of the prodromal patients at 6 months and for 54% at 12 months. CONCLUSIONS: In small groups of subjects, these diagnostic criteria for the schizophrenic prodrome and the Structured Interview for Prodromal Syndromes showed promising interrater reliability and predictive validity.