Meta-analysis of 41 Functional Neuroimaging Studies of Executive Function in Schizophrenia

作者：Michael Minzenberg, Angela R. Laird, Sarah M. Thelen, Cameron S. Carter, David C. Glahn · 发表于：Archives of General Psychiatry · 年份：2009 · DOI：10.1001/archgenpsychiatry.2009.91 · 被引用次数：1171 · 研究领域：Schizophrenia research and treatment、Cognitive Functions and Memory、Functional Brain Connectivity Studies

CONTEXT: Prefrontal cortical dysfunction is frequently reported in schizophrenia. It remains unclear whether this represents the coincidence of several prefrontal region- and process-specific impairments or a more unitary dysfunction in a superordinate cognitive control network. Whether these impairments are properly considered reflective of hypofrontality vs hyperfrontality remains unresolved. OBJECTIVES: To test whether common nodes of the cognitive control network exhibit altered activity across functional neuroimaging studies of executive cognition in schizophrenia and to evaluate the direction of these effects. DATA SOURCES: PubMed database. STUDY SELECTION: Forty-one English-language, peer-reviewed articles published prior to February 2007 were included. All reports used functional neuroimaging during executive function performance by adult patients with schizophrenia and reported whole-brain analyses in standard stereotactic space. Tasks primarily included the delayed match-to-sample, N-back, AX-CPT, and Stroop tasks. DATA EXTRACTION: Activation likelihood estimation modeling reported activation maxima as the center of a 3-dimensional gaussian function in the meta-analysis, with statistical thresholding and correction for multiple comparisons. DATA SYNTHESIS: In within-group analyses, healthy controls and patients activated a similarly distributed cortical-subcortical network, prominently including the dorsolateral prefrontal cortex (PFC), ventrolateral PFC, anterior c...