Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension

作者：Baogang Wu, Ying Hao, Jin Shi, Ning Geng, Tiejun Li, Yanli Chen, Zhaoqing Sun, Liqiang Zheng, Hong Li, Naijing Li, Xingang Zhang, Yingxian Sun · 发表于：Molecular Medicine Reports · 年份：2015 · DOI：10.3892/mmr.2015.4135 · 被引用次数：21 · 研究领域：Gout, Hyperuricemia, Uric Acid、Folate and B Vitamins Research、Alcohol Consumption and Health Effects

The present study aimed to investigate the association between xanthine dehydrogenase (XDH) gene polymorphism and essential hypertension in the rural Han Chinese population of Fuxin, Liaoning. Han Chinese individuals, who had lived in rural areas of Fuxin, were selected as subjects for the present study. A total of 521 unrelated patients with hypertension were selected, along with a further 533 unrelated individuals with normal blood pressure, in order to serve as controls. Five tag single nucleotide polymorphisms (SNP) of the XDH gene were selected. An estimation of SNP allele frequency was determined using DNA pooling and pyrosequencing methods. Prior to Bonferroni correction, T allele frequency for rs206811 was significantly higher in patients with hypertension, as compared with the controls (64.1 vs. 59.4%; P=0.031); C allele frequency for rs1042039 was significantly higher in patients with hypertension, as compared with the controls (66.1 vs. 60.6%; P=0.011), C allele frequency for rs1054889 was significantly lower in patients with hypertension, as compared with the controls (38.8 vs. 44.8%; P=0.007); and A allele frequency for rs2073316 was significantly lower in patients with hypertension, as compared with the controls (29.2 vs. 34.4%; P=0.013). However, once a Bonferroni correction for multiple testing was applied, the XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 were shown to be associated with hypertension (P=0.044, 0.035, and 0.039, respectively). The...