Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group

作者：Jamie K. Waselenko, Thomas J. MacVittie, William F. Blakely, Nicki Pesik, Albert L. Wiley, William E. Dickerson, Horace Tsu, Dennis L. Confer, C. Norman Coleman, Thomas Seed, Patrick Lowry, James O. Armitage, Nicholas Dainiak · 发表于：Annals of Internal Medicine · 年份：2004 · DOI：10.7326/0003-4819-140-12-200406150-00015 · 被引用次数：770 · 研究领域：Effects of Radiation Exposure、Childhood Cancer Survivors' Quality of Life、Burn Injury Management and Outcomes

Physicians, hospitals, and other health care facilities will assume the responsibility for aiding individuals injured by a terrorist act involving radioactive material. Scenarios have been developed for such acts that include a range of exposures resulting in few to many casualties. This consensus document was developed by the Strategic National Stockpile Radiation Working Group to provide a framework for physicians in internal medicine and the medical subspecialties to evaluate and manage large-scale radiation injuries. Individual radiation dose is assessed by determining the time to onset and severity of nausea and vomiting, decline in absolute lymphocyte count over several hours or days after exposure, and appearance of chromosome aberrations (including dicentrics and ring forms) in peripheral blood lymphocytes. Documentation of clinical signs and symptoms (affecting the hematopoietic, gastrointestinal, cerebrovascular, and cutaneous systems) over time is essential for triage of victims, selection of therapy, and assignment of prognosis. Recommendations based on radiation dose and physiologic response are made for treatment of the hematopoietic syndrome. Therapy includes treatment with hematopoietic cytokines; blood transfusion; and, in selected cases, stem-cell transplantation. Additional medical management based on the evolution of clinical signs and symptoms includes the use of antimicrobial agents (quinolones, antiviral therapy, and antifungal agents), antiemetic agent...