Water: The Ideal Hydrogen‐Atom Source in Free‐Radical Chemistry Mediated by TiIII and Other Single‐Electron‐Transfer Metals?

作者：Juan M. Cuerva, Araceli G. Campaña, José Justicia, Antonio Rosales, Juan L. Oller‐López, Rafael Azevedo Robles, Diego J. Cárdenas, Elena Buñuel, Juan Enrique Oltra · 发表于：Angewandte Chemie International Edition · 年份：2006 · DOI：10.1002/anie.200600831 · 被引用次数：209 · 研究领域：Oxidative Organic Chemistry Reactions、Polyoxometalates: Synthesis and Applications、Catalytic C–H Functionalization Methods

Hydrogen-atom transfer from water to free radicals can be mediated by aqua complexes of titanium(III) (see scheme). Asymmetric epoxidation in combination with [Cp2TiCl]/H2O-mediated reductive epoxide opening can be viewed as an alternative with complementary stereoselectivity to the hydroboration–epoxidation method for the enantioselective synthesis of anti-Markovnikov alcohols from alkenes.