The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

作者：Paul M. Thompson, Jason L. Stein, Sarah Elizabeth Medland, Derrek P. Hibar, Alejandro Arias Vásquez, Miguel E. Rentería, Roberto Toro, Neda Jahanshad, Günter Schumann, Barbara Franke, Margaret J. Wright, Nicholas G. Martin, Ingrid Agartz, Martin Alda, Saud Alhusaini, Laura A. Almasy, Jorge Almeida, Kathryn I. Alpert, Nancy C. Andreasen, Ole A. Andreassen, Liana G. Apostolova, Katja Appel, Nicola Jane Armstrong, Benjamin S. Aribisala, Mark E. Bastin, Michael S. Bauer, Carrie E. Bearden, Ørjan Bergmann, Elisabeth B. Binder, John Blangero, H. Jeremy Bockholt, Erlend Bøen, Catherine Bois, Dorret Irene Boomsma, Tom Booth, Ian Bowman, Janita Bralten, Rachel M. Brouwer, Han G. Brunner, David G. Brohawn, Randy Lee Buckner, Jan K. Buitelaar, Kazima Bulayeva, Juan Bustillo, Vince D. Calhoun, Dara M. Cannon, Rita M. Cantor, Melanie A. Carless, Xavier Caseras, Gianpiero L. Cavalleri, M. Mallar Chakravarty, Kiki Chang, Christopher R. K. Ching, Andrea Christoforou, Sven Cichon, Vincent P. Clark, Patricia Conrod, Giovanni Coppola, Benedicto Crespo‐Facorro, Joanne E. Curran, Michael Czisch, Ian J. Deary, Eco J. C. de Geus, Anouk den Braber, Giuseppe Delvecchio, Chantal Depondt, Lieuwe de Haan, Greig Ian de Zubicaray, Danai Dima, Ralica Dimitrova, Srdjan Djurovic, Hong‐Wei Dong, Gary J Donohoe, Ravindranath Duggirala, Thomas D. Dyer, Stefan Ehrlich, Carl Johan Ekman, Torbjørn Elvsåshagen, Louise Emsell, Susanne Erk, Thomas Espeseth, Jesen A. Fagerness, Scott C. Fears, Iryna O. Fedko, Guillén Fernández, Simon E. Fisher, Tatiana Foroud, Peter T. Fox, Clyde Francks, Sophia Frangou, Eva Maria Frey, Thomas Frodl, Vincent Frouin, Hugh P Garavan, Sudheer Giddaluru, David C. Glahn, Beata R. Godlewska, Rita Z. Goldstein, Randy L. Gollub, Hans Jörgen Grabe, Oliver R. Grimm, Oliver Gruber, Tulio M. Guadalupe, Raquel E. Gur, Ruben C. Gur, Harald H.H. Göring, Saskia P. Hagenaars, Tomáš Hájek, Geoffrey B. Hall, Jérémy Hall, John Hardy, Catharina Annette Hartman, Johanna Haß, Sean N. Hatton, Unn Kristin Haukvik, Katrin Hegenscheid, Andreas Heinz, Ian Bernard Hickie, Beng‐Choon Ho, David Hoehn, Pieter J. Hoekstra, Marisa O. Hollinshead, Avram J. Holmes, Georg Homuth, Martine Hoogman, L. Elliot Hong, Norbert Hosten, Jouke‐Jan Hottenga, Hilleke E. Hulshoff Pol, Kristy Hwang, Clifford R. Jack, Mark Jenkinson, Caroline Johnston, Erik Gunnar Jönsson, René S. Kahn, Dalia Kasperavičiūtė, Sinéad Kelly, Sungeun Kim, Peter V Kochunov, Laura Koenders, Bernd Krämer, John B. Kwok, Jim Lagopoulos, Gonzalo Laje, Mikael Landén, Bennett A. Landman, John Lauriello, Stephen M. Lawrie, Phil Hyoun Lee, Stéphanie Le Hellard, Hervé Lemaître, Cassandra D. Leonardo, Chiang-shan Li, Benny Liberg, David C M Liewald, Xinmin Liu, Lorna M. Lopez, Eva Loth, Anbarasu Lourdusamy, Michelle Luciano, Fabio M. Macciardi, Marise W. J. Machielsen, GLENDA M. MacQUEEN, Ulrik Fredrik Malt, René C.W. Mandl, Dara S. Manoach, Jean‐Luc Martinot, Mar Matarín, Karen A. Mather, Manuel Mattheisen, Morten Mattingsdal, Andreas Meyer‐Lindenberg, Colm McDonald, Andrew Mark McIntosh, Francis J. McMahon, Katie Louise McMahon, Eva Maria Meisenzahl, Ingrid S. Melle, Yuri Milaneschi, Sebastian Mohnke, Grant W. Montgomery, Derek W. Morris, Eric Keith Moses, Bryon A. Mueller, Susana Muñoz Maniega, Thomas W. Mühleisen, Bertram Müller‐Myhsok, Benson Mwangi, Matthias A. Nauck, Kwangsik T. Nho, Thomas E. Nichols, Lars-Göran Nilsson, Allison Carol Nugent, Lars H Nyberg, Rene Luis Olvera, Jaap Oosterlaan, Roel A. Ophoff, Massimo Pandolfo, Melina Papalampropoulou-Tsiridou, Martina Papmeyer, Tomáš Paus, Zdenka Pausová, Godfrey D. Pearlson, Brenda W.J.H. Penninx, Charles P. Peterson, Andrea Pfennig, Mary Louise Phillips, G. Bruce Pike, Jean‐Baptiste Poline, Steven G. Potkin, Benno Pütz, Adaikalavan Ramasamy, Jerod M. Rasmussen, Marcella Rietschel, Mark Rijpkema, Shannon L. Risacher, Joshua L. Roffman, Roberto Roiz‐Santiáñez, Nina Romanczuk‐Seiferth, Emma J. Rose, Natalie A. Royle, Dan Rujescu, Mina Ryten, Perminder Singh Sachdev, Alireza Salami, Theodore Daniel Satterthwaite, Jonathan B. Savitz, Andrew J. Saykin, Cathy Scanlon, Lianne Schmaal, Hugo Gerard Schnack, Andrew Joseph Schork, S. Charles Schulz, Remmelt R. Schür, Larry J. Seidman, Li Shen, Jody M. Shoemaker, Andrew D. Simmons, Sanjay M. Sisodiya, Colin Smith, Jordan W. Smoller, Jair C. Soares, Scott R. Sponheim, Emma Sprooten, John M. Starr, Vidar M. Steen, Stephen M. Strakowski, Lachlan T. Strike, Jessika Elizabeth Sussmann, Philipp Gero Sämann, Alexander Teumer, Arthur W. Toga, Diana Tordesillas‐Gutiérrez, Daniah Trabzuni, Sarah E. Trost, Jessica A. Turner, Martijn P. van den Heuvel, Nic JA van der Wee, Kristel van Eijk, Theo G.M. van Erp, Neeltje E. M. van Haren, Dennis van ‘t Ent, Marie‐José van Tol, Maria C. Valdés Hernández, Dick J. Veltman, Amelia Versace, Henry Völzke, ROBERT E. WALKER, Henrik Walter, Lei Wang, Joanna Marguerite Wardlaw, Michael E. Weale, Michael Walter Weiner, Wei Xiong Wen, Lars Tjelta Westlye, Heather Clare Whalley, Christopher D. Whelan, Tonya J.H. White, Anderson M. Winkler, Katharina Wittfeld, Girma Woldehawariat, Christiane Wolf, David Zilles‐Wegner, Marcel P. Zwiers, Anbupalam Thalamuthu, Peter R. Schofield, Nelson B. Freimer, Natalia Sophie Lawrence, Wayne Curtis Drevets · 发表于：Brain Imaging and Behavior · 年份：2014 · DOI：10.1007/s11682-013-9269-5 · 被引用次数：891 · 研究领域：Functional Brain Connectivity Studies、Genetic Associations and Epidemiology、Advanced Neuroimaging Techniques and Applications

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.