TREATMENT OF POST‐MENOPAUSAL HYPERCHOLEROLAEMIA WITH ESTRADIOL

作者：Matti J. Tikkanen, T Kuusi, Erkki Vartiainen, EskoA Nikkilä · 发表于：Acta Obstetricia Et Gynecologica Scandinavica · 年份：1979 · DOI：10.3109/00016347909157234 · 被引用次数：71 · 研究领域：Lipoproteins and Cardiovascular Health、Hormonal and reproductive studies、Antioxidant Activity and Oxidative Stress

Replacement therapy with estradiol valerate in 29 post-menopausal women reduced low-density lipoprotein (LDL) cholesterol concentrations by 22% and increased high-density lipoprotein (HDL) cholesterol by 21% after 12 months. Apart from a 67% increase of HDL-triglyceride estradiol had only a slight effect on the levels of lipoprotein triglycerides. Post-heparin plasma lipoprotein lipase (LPL) activity was significantly decreased in subjects with normal pre-treatment very-low-density lipoprotein (VLDL) triglyceride levels, and hepatic lipase (HL) activity was significantly decreased in the group as a whole. It is suggested that estradiol replacement therapy should be considered in climacteric women with high LDL-cholesterol or low HDL-cholesterol levels, or both.