Cardiopulmonary Function and Age-Related Decline Across the Breast Cancer Survivorship Continuum

作者：Lee W. Jones, Kerry S. Courneya, John R. Mackey, Hyman B. Muss, Edith Pituskin, Jessica M. Scott, Whitney Hornsby, April Coan, James E. Herndon, Pamela S. Douglas, Mark J. Haykowsky · 发表于：Journal of Clinical Oncology · 年份：2012 · DOI：10.1200/jco.2011.39.9014 · 被引用次数：447 · 研究领域：Chemotherapy-induced cardiotoxicity and mitigation、Cancer Risks and Factors、Cardiovascular and exercise physiology

PURPOSE: To evaluate cardiopulmonary function (as measured by peak oxygen consumption [VO(2peak)]) across the breast cancer continuum and its prognostic significance in women with metastatic disease. PATIENTS AND METHODS: Patients with breast cancer representing four cross-sectional cohorts--that is, (1) before, (2) during, and (3) after adjuvant therapy for nonmetastatic disease, and (4) during therapy in metastatic disease--were studied. A cardiopulmonary exercise test (CPET) with expired gas analysis was used to assess VO(2peak). A Cox proportional hazards model was used to estimate the risk of death according to VO(2peak) category (< 15.4 v ≥ 15.4 mL · kg(-1) · min(-1)) with adjustment for clinical factors. RESULTS: A total of 248 women (age, 55 ± 8 years) completed a CPET. Mean VO(2peak) was 17.8 ± a standard deviation of 4.3 mL · kg(-1) · min(-1), the equivalent of 27% ± 17% below age-matched healthy sedentary women. For the entire cohort, 32% had a VO(2peak) less than 15.4 mL · kg(-1) · min(-1)--the VO(2peak) required for functional independence. VO(2peak) was significantly different across breast cancer cohorts for relative (mL · kg(-1) · min(-1)) and absolute (L · min(-1)) VO(2peak) (P = .017 and P < .001, respectively); VO(2peak) was lowest in women with metastatic disease. In patients with metastatic disease (n = 52), compared with patients achieving a VO(2peak) ≤ 1.09 L · min(-1), the adjusted hazard ratio for death was 0.32 (95% CI, 0.16 to 0.67, P = .002) for a ...