An Assessment of Prednisone, Salazopyrin, and Topical Hydrocortisone Hemisuccinate Used as Out-patient Treatment for Ulcerative Colitis

作者：J E Lennard‐Jones, Avery Longmore, A. C. Newell, Carlie Wilson, F. Avery Jones · 发表于：Gut · 年份：1960 · DOI：10.1136/gut.1.3.217 · 被引用次数：230 · 研究领域：Inflammatory Bowel Disease、Microscopic Colitis、Helicobacter pylori-related gastroenterology studies

Two consecutive trials of out-patient treatment for mild cases of active ulcerative colitis are described. In the first trial oral prednisone gave significantly better results than a placebo. In the second trial "salazopyrin" gave final results approaching those of prednisone, although over a longer time and with a higher incidence of unpleasant side-effects, but topical hydrocortisone gave disappointing results, probably because the technique of administration was not suitable for ordinary out-patient use.