Two-year outcomes in patients admitted with non-ST elevation acute coronary syndrome: results of the OASIS registry 1 and 2.

作者：Dorairaj Prabhakaran, Salim Yusuf, Shamir R. Mehta, Janice M. Pogue, Álvaro Avezum, Andrzej Budaj, Leszek Cerumzynski, Marcus D Flather, Keith A.A. Fox, David U. Hunt, Liu Lisheng, Mátyás Keltai, Alexander N. Parkhomenko, Prem Pais, Srinath Reddy, Mikhail Ruda, Tan Hiquing, Zhu Jun · 发表于：PubMed · 年份：2005 · 被引用次数：91 · 研究领域：Acute Myocardial Infarction Research、Cardiac Health and Mental Health、Heart rate and cardiovascular health

BACKGROUND: Acute coronary syndrome continues to have significant long-term morbidity and mortality. This study sought to compare baseline characteristics, practice patterns and clinical outcomes for patients with non-ST elevation acute coronary syndrome from a broad range of low-, middle- and high-income countries. METHODS AND RESULTS: We compared the data from a prospective registry of patients with non-ST elevation acute coronary syndrome involving 4615 patients from 65 centers in 8 low and middle income countries (OASIS registry 2) with those obtained from 7987 patients from 95 centers in 6 middle and high income countries (OASIS registry 1). Patients in the OASIS registry 2 were younger, were more often males and smokers, presented later to the hospital after symptom onset and had a lower prevalence of diabetes at admission [with the exception of India, which had the highest age-adjusted prevalence (39.1%)]. There were marked variations in the angiography and intervention rates during the hospital stay, but the uses of proven pharmacological therapies were comparable. The two-year mortality rates adjusted for baseline covariates ranged from 6.9% to 15%. Patients from China had the lowest two-year mortality rate (6.9%) and patients from India had the highest rate (15%). Combining the two registries, the covariate-adjusted rate of death or myocardial infarction did not differ across countries with in-hospital angiographic rates of > or = 50% (17.1%), 25-49% (16.7%) or < 25...