Development of Monocytes, Macrophages, and Dendritic Cells

作者：Frédéric Geissmann, Markus G. Manz, Steffen Jung, Michael H. Sieweke, Miriam Mérad, Klaus Ley · 发表于：Science · 年份：2010 · DOI：10.1126/science.1178331 · 被引用次数：3035 · 研究领域：Immunotherapy and Immune Responses、Immune cells in cancer、Immune Response and Inflammation

Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated.