Cytotoxic T-Lymphocyte-Associated Antigen-4 Blockage Can Induce Autoimmune Hypophysitis in Patients With Metastatic Melanoma and Renal Cancer

作者：Joseph Blansfield, Kimberly E Beck, Khoi N. Tran, James Chih‐Hsin Yang, Marybeth S. Hughes, Udai S. Kammula, Richard Eldon Royal, Suzanne Louise Topalian, Leah R. Haworth, Catherine L. Levy, Steven A. Rosenberg, Richard Mark Sherry · 发表于：Journal of Immunotherapy · 年份：2005 · DOI：10.1097/01.cji.0000178913.41256.06 · 被引用次数：358 · 研究领域：T-cell and B-cell Immunology、Diabetes and associated disorders、Cancer Immunotherapy and Biomarkers

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4CD25 T cells. In patients with advanced melanoma, our group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of patients. This study also established that the blockade of CTLA-4 was associated with grade III/IV autoimmune manifestations that included dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial report, 7 additional patients with anti-CTLA-4 antibody-induced autoimmune hypophysitis have been accumulated. The characteristics, clinical course, laboratory values, radiographic findings, and treatment of these 8 patients are the focus of this report.