Development of coronary collateral circulation in left circumflex Ameroid-occluded swine myocardium

作者：David M. Roth, Yuji Maruoka, J Rogers, F. C. White, John C. Longhurst, Colin M. Bloor · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：1987 · DOI：10.1152/ajpheart.1987.253.5.h1279 · 被引用次数：125 · 研究领域：Cardiac Ischemia and Reperfusion、Cardiomyopathy and Myosin Studies、Cardiac Valve Diseases and Treatments

Coronary collateral development was examined in 34 pigs after gradual occlusion of the left circumflex coronary artery (LCX) with an Ameroid constrictor. Collateral development was assessed by measurements of myocardial blood flow and regional myocardial function at rest and during exercise over a 16-wk period after placement of the constrictor. Coronary collateral development was adequate to prevent severe infarction and restore blood flow to the collateral-dependent LCX region within 3-7 wk. Infarction averaged 5.0 +/- 1.3% of the LCX region. Blood flows at rest were 1.05 +/- 0.14 and 1.13 +/- 0.15 ml.min-1.g-1 in the subendocardium of the collateral and control regions, respectively, 7 wk postoperatively. Concurrently, collateral vessel development supported normal myocardial function at rest as determined by systolic wall thickening in the LCX region. However, collateral development was limited, since blood flows during moderate and severe exercise were reduced in the LCX region compared with control and left anterior descending and right coronary regions. Blood flow ratios (collateral/control flow) during severe exercise 3 wk postoperatively were 0.23 +/- 0.03 and 0.57 +/- 0.05 in the subendocardium and subepicardium and were constant throughout the 16-wk period throughout the study. Myocardial function of the collateral region also was reduced during exercise and a 30-min recovery period. We suggest that this limited coronary collateral circulation, which develops in re...