Interaction of a Golgi-Associated Kinesin-Like Protein with Rab6

作者：Arnaud Échard, Florence Jollivet, Olivier Martinez, Jean-Jacques Lacapère, Annie Rousselet, Isabelle Janoueix‐Lerosey, Bruno Goud · 发表于：Science · 年份：1998 · DOI：10.1126/science.279.5350.580 · 被引用次数：524 · 研究领域：Cellular transport and secretion、Microtubule and mitosis dynamics、Pancreatic function and diabetes

Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.