IL-17E, a Novel Proinflammatory Ligand for the IL-17 Receptor Homolog IL-17Rh1

作者：James Christopher Lee, Wei-Hsien Ho, Miko Maruoka, Racquel T. Corpuz, Daryl T. Baldwin, Jessica Foster, Audrey D. Goddard, Daniel G. Yansura, RICHARD L. VANDLEN, William I. Wood, Austin L. Gurney · 发表于：Journal of Biological Chemistry · 年份：2001 · DOI：10.1074/jbc.m008289200 · 被引用次数：415 · 研究领域：Psoriasis: Treatment and Pathogenesis、Cytokine Signaling Pathways and Interactions、Immunodeficiency and Autoimmune Disorders

We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in multiple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8.