Degradation of Activated Protein Kinases by Ubiquitination

作者：LU Zhi-min, Hunter Tony · 发表于：Annual Review of Biochemistry · 年份：2009 · DOI：10.1146/annurev.biochem.013008.092711 · 被引用次数：144 · 研究领域：Ubiquitin and proteasome pathways、Cancer-related Molecular Pathways、Microtubule and mitosis dynamics

Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases.