Comparative genomics of the lactic acid bacteria

作者：Kira S. Makarova, Alexeï Slesarev, Yuri I. Wolf, Alexeï Sorokin, Boris Mirkin, Eugene V. Koonin, А. В. Павлов, N. V. Pavlova, Valeri N. Karamychev, Nikolai Polouchine, VV Shakhova, Igor V. Grigoriev, Yunian Lou, Daniel S. Rohksar, Susan Lucas, Kunlun Huang, David Goodstein, Trevor Hawkins, Vethachai Plengvidhya, Dennis L. Welker, Judith M. Hughes, Yong Jun Goh, Andrew K. Benson, Kathleen A. Baldwin, Jung Lee, I. Díaz-Muñiz, B. Dosti ., Smeianov Vv, W. Patrick Wechter, Ravi D. Barabote, Graciela L. Lorca, Eric Altermann, Rodolphe Barrangou, Balasubramanian Ganesan, Yi Xie, Helen Rawsthorne, Dafna Tamir, C Parker, Fred Breidt, Jeffery R. Broadbent, Robert W. Hutkins, Daniel J. O’Sullivan, J. L. Steele, G. Unlu, Milton H. Saier, Todd R. Klaenhammer, Paul Richardson, Sergei A. Kozyavkin, Bart C. Weimer, David A. Mills · 发表于：Proceedings of the National Academy of Sciences · 年份：2006 · DOI：10.1073/pnas.0607117103 · 被引用次数：1384 · 研究领域：Genomics and Phylogenetic Studies、Probiotics and Fermented Foods、Microbial Metabolites in Food Biotechnology

Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages. We report nine genome sequences representing the phylogenetic and functional diversity of these bacteria. The small genomes of lactic acid bacteria encode a broad repertoire of transporters for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities that indicate both prototrophic and auxotrophic strains. Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.