Gram‐Positive Antimicrobial Activity of Amino Acid‐Based Hydrogels

作者：I. Irwansyah, Yongqiang Li, Wenxiong Shi, Dianpeng Qi, Wan Ru Leow, Mark Boon Yang Tang, Shuzhou Li, Xiaodong Chen · 发表于：Advanced Materials · 年份：2014 · DOI：10.1002/adma.201403339 · 被引用次数：225 · 研究领域：Antimicrobial Peptides and Activities、Supramolecular Self-Assembly in Materials、Bacteriophages and microbial interactions

Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.