Role of the Intestinal Flora in Major Trauma

作者：Peter Woodruff, D. I. O'Carroll, S. Koizumi, J. Fine · 发表于：The Journal of Infectious Diseases · 年份：1973 · DOI：10.1093/infdis/128.supplement_1.s290 · 被引用次数：70 · 研究领域：Immune Response and Inflammation、Thermal Regulation in Medicine、Nosocomial Infections in ICU

The Limulus-lysate test revealed endotoxin in postmortem tissue homogenates of 20 of a random series of 35 patients. Data indicated that the finding of endotoxin in the livers of these patients signified an endotoxemia consequent on a failure of the endotoxin-detoxifying mechanisms. Endotoxemia was associated with a high incidence of gastrointestinal bleeding, hemorrhagic ulceration of the gastrointestinal mucosa, acute pulmonary pathology, and major injury to the liver. The absence of a septic focus as a source for endotoxemia in many of these patients is consistent with evidence that endotoxemia of intestinal origin commonly develops when the antibacterial defense mechanism has been depleted as a result of severe damage to the reticuloendothelial system.