An Evaluation of the Relative Sensitivities of the Venereal Disease Research Laboratory Test and the Treponema pallidum Particle Agglutination Test Among Patients Diagnosed With Primary Syphilis

作者：Linda Creegan, Heidi M. Bauer, Michael C. Samuel, Jeffrey David Klausner, Sally Liska, GAIL A. BOLAN · 发表于：Sexually Transmitted Diseases · 年份：2007 · DOI：10.1097/olq.0b013e3181124473 · 被引用次数：66 · 研究领域：Syphilis Diagnosis and Treatment、Reproductive tract infections research、Tattoo and Body Piercing Complications

In Brief Background: Because definitive methods for diagnosing primary syphilis are limited, it is important to optimize the sensitivity of serodiagnosis. Objective: To determine the most sensitive testing approach to the diagnosis of primary syphilis, using the commonly available serologic tests: the Venereal Disease Research Laboratory (VDRL) test and the Treponema pallidum particle agglutination (TP-PA) test. Methods: Sensitivities of 2 serologic testing strategies for primary syphilis were compared among 106 darkfield-confirmed cases treated in San Francisco from January 2002 through December 2004. Results: The sensitivity of the diagnostic strategy using VDRL confirmed by TP-PA was 71% (95% CI, 61%–79%). Substituting Rapid Plasma Reagin test for VDRL in a subset of 51 patients produced the same sensitivity (71%; 95% CI, 56%–83%). The sensitivity of TP-PA as the first-line diagnostic test was 86% (95% CI, 78%–92%). The sensitivity of the former approach was significantly lower among HIV-positive patients, compared with HIV-negative patients (55% vs. 77%, P = 0.05). Conclusions: The TP-PA test as the first-line diagnostic test yielded higher sensitivity for primary syphilis than did the use of the currently recommended strategy. Among darkfield-confirmed primary syphilis cases, diagnostic sensitivity was maximized using the Treponema pallidum particle agglutination serologic test as the first-line test, rather than the Venereal Disease Research Laboratory serologic test wi...