Stimulation or suppression of metastases with graded doses of tumor cells.

作者：R Vanwijck, Elizabeth A. Godrick, Howard G. Smith, Jonathan Goldweitz, Richard E. Wilson · 发表于：PubMed · 年份：1971 · 被引用次数：15 · 研究领域：Beetle Biology and Toxicology Studies、Cancer Diagnosis and Treatment、Organ and Tissue Transplantation Research

Varying doses of syngeneic fibrosarcoma cells, injected into the left limb at the time of amputation of the right tumor-bearing limb, either augmented or inhibited development of lung metastases in mice. Two different tumors were investigated, and with each 1 × 104 live tumor cells provided complete protection from metastases. In both tumor lines, increasing the number of live tumor cells or using irradiated tumor cells at equivalent or greater dosage increased the incidence of metastases.