The Epidemiology of Haemophilus influenzae Meningitis in Children under Five Years of Age in The Gambia, West Africa

作者：Henk A. Bijlmer, L van Alphen, Brian M. Greenwood, James A. Brown, Gisela Schneider, Angus E. Hughes, Arun Menon, H. C. Zanen, H. A. Valkenburg · 发表于：The Journal of Infectious Diseases · 年份：1990 · DOI：10.1093/infdis/161.6.1210 · 被引用次数：81 · 研究领域：Bacterial Infections and Vaccines、Virology and Viral Diseases、Pneumonia and Respiratory Infections

Haemophilus influenzae meningitis was studied over a 2-year period in children less than 5 years of age in a population-based, prospective study in The Gambia, West Africa. A total of 77 cases were recorded. The incidence was 60 cases/100,000 children less than 5 years of age and 297 cases/100,000 children less than 1 year of age. The peak prevalence was at the age of 5 months; 83% of the children were less than 1 year old and 45% were less than 6 months old. Only 55% of cases recovered completely. The distance to the nearest hospital was an important predisposing factor for a fatal outcome. Two cases were secondary. Many patients were anemic and underweight. The observations show that H. influenzae meningitis in The Gambia has an incidence as high as that in the USA, but that it has 10-fold more devastating outcome. If the infection is to be prevented by vaccination in The Gambia, immunization will have to be given very early in life.