The Glycoprotein of Vesicular Stomatitis Virus Is the Antigen That Gives Rise to and Reacts with Neutralizing Antibody

作者：James Kelley, Suzanne Urjil Emerson, Robert R. Wagner · 发表于：Journal of Virology · 年份：1972 · DOI：10.1128/jvi.10.6.1231-1235.1972 · 被引用次数：222 · 研究领域：Glycosylation and Glycoproteins Research、T-cell and Retrovirus Studies、Animal Disease Management and Epidemiology

The glycoprotein, but no other virion protein, of vesicular stomatitis virus was solubilized by the nonionic detergent Triton X-100 in low ionic strength buffer. The solubilized viral glycoprotein induced the synthesis of antibody that formed a single precipitin line with the glycoprotein and that neutralized the infectivity of the virus. The neutralizing activity of the antibody was efficiently blocked by purified glycoprotein.