Hypoglycaemic Potential of Mangifera indica Leaves in Rats

作者：Sonia Sharma, Shailendra Kumar Dhar Dwivedi, Devendra Swarup · 发表于：Pharmaceutical Biology · 年份：1997 · DOI：10.1076/phbi.35.2.130.13276 · 被引用次数：21 · 研究领域：Mangiferin and Mango Extracts、Natural Antidiabetic Agents Studies、Psidium guajava Extracts and Applications

Hypoglycaemic activity of 50% ethanol extract of Mangifera indica tender leaves was studied in normal and streptozotocin induced diabetic rats. In normal rats, the extract was administered only once in doses of 100, 250 and 500 mg/kg per os. The highest decrease (37.73%) in plasma glucose levels was obtained with 250 mg dose after 8 h of administration. In diabetic rats, the extract produced significant antihyperglycaemic effect within 3 days when given at 250 mg/kg/day per os for 10 days. LD 50 of the extract was above 4.64 gm/kg per os.