Mechanism of cholesterol efflux from cells. Effects of acceptor structure and concentration.

作者：George H. Rothblat, Michael C. Phillips · 发表于：Journal of Biological Chemistry · 年份：1982 · DOI：10.1016/s0021-9258(18)34593-9 · 被引用次数：182 · 研究领域：Cholesterol and Lipid Metabolism、Lipid Membrane Structure and Behavior、Lipid metabolism and biosynthesis

The kinetics of removal of [3H]cholesterol from Fu5AH rat hepatoma, WIRL-3C rat liver cells, and hu- man skin fibroblasts growing in culture to phospho- lipid-containing acceptor particles in the extracellular medium (0.05-1.2 mg of phosphatidylcholine (PC)/ml) has been measured. The rate of release of at least one- third of the cholesterol in these cells in either mono- layer or suspension culture is