Blood pressure in relation to general and central adiposity among 500 000 adult Chinese men and women

作者：Zhengming Chen, Margaret C Smith, Huaidong Du, Canqing Yu, Robert Clarke, Zheng Bian, Rory Collins, Junshi Chen, Yijian Qian, Xiaoping Wang, Xiaofang Chen, Xiaocao Tian, Xiaohuan Wang, Richard Peto, Liming Li, for the China Kadoorie Biobank Collaborative Group · 发表于：International Journal of Epidemiology · 年份：2015 · DOI：10.1093/ije/dyv012 · 被引用次数：55 · 研究领域：Blood Pressure and Hypertension Studies、Diabetes, Cardiovascular Risks, and Lipoproteins、Obesity, Physical Activity, Diet

BACKGROUND: Greater adiposity is associated with higher blood pressure. Substantial uncertainty remains, however, about which measures of adiposity most strongly predict blood pressure and whether these associations differ materially between populations. METHODS: We examined cross-sectional data on 500 000 adults recruited from 10 diverse localities across China during 2004-08. Multiple linear regression was used to estimate the effects on systolic blood pressure (SBP) of general adiposity [e.g. body mass index (BMI), body fat percentage, height-adjusted weight] vs central adiposity [e.g. waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR)], before and after adjustment for each other. The main analyses excluded those reported taking any antihypertensive medication, and were adjusted for age, region and education. RESULTS: The overall mean [standard deviation (SD)] BMI was 23.6 (3.3) kg/m(2) and mean WC was 80.0 (9.5) cm. The differences in SBP (men/women, mmHg) per 1SD higher general adiposity (height-adjusted weight: 6.6/5.6; BMI: 5.5/4.9; body fat percentage: 5.5/5.0) were greater than for central adiposity (WC: 5.0/4.3; HC: 4.8/4.1; WHR: 3.7/3.2), with a 10 kg/m(2) greater BMI being associated on average with 16 (men/women: 17/14) mmHg higher SBP. The associations of blood pressure with measures of general adiposity were not materially altered by adjusting for WC and HC, but those for central adiposity were significantly attenuated after adjusting for B...