Multi-site cyclization via initial C–H activation using a rhodium( iii ) catalyst: rapid assembly of frameworks containing indoles and indolines

作者：Ji‐Rong Huang, Qin Liu, Yuqin Zhu, Qiang Song, Lin Dong · 发表于：Chemical Communications · 年份：2015 · DOI：10.1039/c4cc07125e · 被引用次数：79 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Cyclopropane Reaction Mechanisms

Tandem multi-site cyclization triggered by Rh(iii)-catalyzed C-H activation has been achieved for highly efficient synthesis of spirocycle indolin-3-one (C2-cyclization), benzo[a]carbazole (C3-cyclization) and an unusual indoxyl core (N1-cyclization). In particular, the synthesis of pseudo-indoxyl is typically completed within 10 min, and the reaction tolerates air, water and a range of solvents.