Water‐Soluble, Donor–Acceptor Biphenyl Derivatives in the 2‐( o ‐Nitrophenyl)propyl Series: Highly Efficient Two‐Photon Uncaging of the Neurotransmitter γ‐Aminobutyric Acid at λ =800 nm

作者：Loïc Donato, Alexandre Mourot, Christopher M. Davenport, Cyril Herbivo, David Warther, Jérémie Léonard, Frédéric Bolze, Jean‐François Nicoud, Richard H. Kramer, Maurice Goeldner, Alexandre Specht · 发表于：Angewandte Chemie International Edition · 年份：2012 · DOI：10.1002/anie.201106559 · 被引用次数：121 · 研究领域：Photochromic and Fluorescence Chemistry、Neuroscience and Neuropharmacology Research、Luminescence and Fluorescent Materials

Rattling the cage: The two γ-aminobutyric acid (GABA) derivatives 1 and 2 exhibit efficient and rapid (<5×10−6 s) GABA photorelease upon one-photon excitation combined with two-photon uncaging cross-section at λ=800 nm. Compounds 1 and 2 were successfully used for two-photon GABA release in intact brain tissue, thus offering attractive perspectives in chemical neurosciences.