The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

作者：John Hardy, Dennis J. Selkoe · 发表于：Science · 年份：2002 · DOI：10.1126/science.1072994 · 被引用次数：13987 · 研究领域：Alzheimer's disease research and treatments、Prion Diseases and Protein Misfolding、Cholinesterase and Neurodegenerative Diseases

It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Abeta in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta clearance.