A Virus Spotlighted by an Autonomous DNA Machine

作者：Yossi Weizmann, Moritz K. Beissenhirtz, Zoya Cheglakov, Roni Nowarski, Moshe Kotler, Itamar Willner · 发表于：Angewandte Chemie International Edition · 年份：2006 · DOI：10.1002/anie.200602754 · 被引用次数：280 · 研究领域：Advanced biosensing and bioanalysis techniques、Biosensors and Analytical Detection、Bacteriophages and microbial interactions

Highly sensitive: Analysis of viral DNA (M13 phage) is possible by using a DNA-based machine that is fueled by dNTPs and synthesizes DNAzyme reporter units. The DNAzymes mimic peroxidase and lead to a colorimetric or chemiluminescent readout of the analyzed DNA.