A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ

作者：Guosheng Tan, Xinping Cao, Qiangsheng Dai, Bing Zhang, Jianwen Huang, Shiqiu Xiong, Yong yu Zhang, Wei Chen, Jianyong Yang, Heping Li · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.3254 · 被引用次数：75 · 研究领域：Hippo pathway signaling and YAP/TAZ、Lipid metabolism and biosynthesis、Wnt/β-catenin signaling in development and cancer

// Guosheng Tan 1, * , Xinping Cao 2, * , Qiangsheng Dai 3, * , Bing Zhang 4 , Jianwen Huang 5 , Shiqiu Xiong 6 , Yong yu Zhang 1 , Wei Chen 1 , Jianyong Yang 1 , Heping Li 1, 3 1 Department of Interventional Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China 2 Department of Radiotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China 3 Department of Medical Oncology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China 4 Department of Nuclear Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China 5 Department of Radiation Oncology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China 6 Department of Biochemistry, University of Leicester, Leicester, UK * These authors have contributed equally to this work Correspondence to: Heping Li, e-mail: drliheping@163.com Jianyong Yang, e-mail: yangjy1959@163.com Keywords: miR-129-5p, YAP, TAZ, cell proliferation, survival Received: November 30, 2014      Accepted: January 28, 2015      Published: April 07, 2015 ABSTRACT Transcriptional co-activator Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are key oncogenes in mammalian cells. Activities of YAP and TAZ are largely restricted by the Hippo tumor suppressor pathway through phosphorylation-ubiquitination mechanisms. The involvement of microRNA in cancer progression has recently bee...