Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress

作者：Mohammad Badran, Najib Ayas, Ismail Laher · 发表于：Oxidative Medicine and Cellular Longevity · 年份：2014 · DOI：10.1155/2014/985258 · 被引用次数：93 · 研究领域：Obstructive Sleep Apnea Research、Neuroscience of respiration and sleep、Cardiovascular and Diving-Related Complications

Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men with a higher prevalence among obese subjects. This condition is considered as an independent risk factor for cerebrovascular and cardiovascular diseases. One of the major pathophysiological characteristics of OSA is intermittent hypoxia. Hypoxia can lead to oxidative stress and overproduction of reactive oxygen species, which can lead to endothelial dysfunction, a hallmark of atherosclerosis. Many animal models, such as the rodent model of intermittent hypoxia, mimic obstructive sleep apnea in human patients and allow more in-depth investigation of biological and cellular mechanisms of this condition. This review discusses the role of oxidative stress in cardiovascular disease resulting from OSA in humans and animal models.