Right Bundle-Branch Block and ST-Segment Elevation in Leads V 1 Through V 3

作者：Josép Brugada, Ramón Brugada, Pedro Brugada · 发表于：Circulation · 年份：1998 · DOI：10.1161/01.cir.97.5.457 · 被引用次数：714 · 研究领域：Cardiac pacing and defibrillation studies、Cardiac Arrhythmias and Treatments、Cardiac electrophysiology and arrhythmias

BACKGROUND: Five years ago, we described a specific ECG pattern of right bundle-branch block and ST-segment elevation in leads V1 through V3 associated with sudden death in patients without demonstrable structural heart disease. Information on long-term outcome has become available due to pooled data on a large cohort of patients with this syndrome who are followed at 33 centers worldwide. METHODS AND RESULTS: Data on 63 patients (57 men; mean age, 38+/-17 years) with the described ECG pattern were analyzed in terms of arrhythmic events and sudden death. Events were analyzed for patients with at least one episode of aborted sudden death or syncope of unknown origin before recognition of the syndrome (symptomatic patients, n=41) and for patients in whom the ECG pattern was recognized by chance or because of screening related to sudden death of a relative (asymptomatic patients, n=22). During a mean follow-up of 34+/-32 months, an arrhythmic event occurred in 14 symptomatic patients (34%) and 6 asymptomatic patients (27%). An automatic defibrillator was implanted in 35 patients, 15 received pharmacological therapy with beta-blockers and/or amiodarone, and 13 did not receive treatment The incidence of arrhythmic events was similar in all therapy groups (log-rank 0.86); however, total mortality was 0% in the implantable defibrillator group, 26% in the pharmacological group, and 31% in the no therapy group (log-rank 0.0005). All mortality was due to sudden death. CONCLUSIONS: Pati...