The matrix‐degrading metalloproteinases

作者：Lynn McCormick Matrisian · 发表于：BioEssays · 年份：1992 · DOI：10.1002/bies.950140705 · 被引用次数：1376 · 研究领域：Protease and Inhibitor Mechanisms、Peptidase Inhibition and Analysis、Signaling Pathways in Disease

The matrix-degrading metalloproteinases are an intriguing family of enzymes that have evolved to digest specific extracellular matrix components. The expression of these enzymes is very highly regulated and can be controlled transcriptionally by a number of growth factors, tumor promoters, oncogenes, and hormones. It is suggested that the coordinated regulation of matrix metalloproteinases and their inhibitors by these agents modify the integrity of the extracellular matrix. These modifications may, at least in part, be responsible for mediating the effects of these factors on complex physiological processes.