Risk of hip fracture in women with vertebral fracture

作者：Mark A. Kotowicz, Lee J. Melton, Cyrus Cooper, Elizabeth J. Atkinson, W. Michael O’Fallon, B. Lawrence Riggs · 发表于：Journal of Bone and Mineral Research · 年份：1994 · DOI：10.1002/jbmr.5650090503 · 被引用次数：137 · 研究领域：Bone health and osteoporosis research、Hip and Femur Fractures、Bone and Joint Diseases

In a population-based retrospective cohort study, Rochester women aged 35-69 years who were first diagnosed with one or more vertebral fractures in 1950-1979 were followed for the development of a subsequent hip fracture. The 336 women with no history of hip fracture at the time of their vertebral fracture experienced 52 proximal femur fractures in 4788 person-years of follow-up. The standardized morbidity ratio (SMR) of observed to expected hip fractures was 1.8 (95% CI, 1.3-2.4) and was higher for intertrochanteric than cervical femoral fractures (SMR, 2.3 versus 1.3; P = 0.07). Hip fracture risk among women with symptomatic vertebral fractures was slightly less than in those with asymptomatic vertebral fractures (SMR, 1.8 versus 2.3; not significant), and younger women had no higher risk of a subsequent hip fracture than women who were > or = 60 years of age at the time of their vertebral fracture (SMR, 1.4 versus 1.8; not significant). Alternative explanations are possible, but these data are consistent with heterogeneity in the pathogenesis of different osteoporotic fractures.