Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats

作者：Li Zhang, Zhijie He, Qí Zhāng, Yi Wu, Xiaojiao Yang, Wenxiu Niu, Yongshan Hu, Jie Jia · 发表于：International Journal of Molecular Sciences · 年份：2014 · DOI：10.3390/ijms15034453 · 被引用次数：49 · 研究领域：Mitochondrial Function and Pathology、ATP Synthase and ATPases Research、Adipose Tissue and Metabolism

Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulates mitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits), which regulate mitochondrial functions, after middle cerebral artery occlusion (MCAO) in rats. T2-weighted magnetic resonance imaging (MRI) was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions.