In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum

作者：Leonardo Kishi Basco, Sofia Mitaku, A.-L. Skaltsounis, N Ravelomanantsoa, François Tillequin, Michel Koch, Jacques Le Bras · 发表于：Antimicrobial Agents and Chemotherapy · 年份：1994 · DOI：10.1128/aac.38.5.1169 · 被引用次数：146 · 研究领域：Malaria Research and Control、Bioactive Compounds and Antitumor Agents、Synthesis and biological activity

The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.