Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

作者：Kristin Schmidt, Philip J. Cowen, Catherine J. Harmer, George Tzortzis, Steven P. Errington, Philip W. J. Burnet · 发表于：Psychopharmacology · 年份：2014 · DOI：10.1007/s00213-014-3810-0 · 被引用次数：530 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Stress Responses and Cortisol

RATIONALE: There is now compelling evidence for a link between enteric microbiota and brain function. The ingestion of probiotics modulates the processing of information that is strongly linked to anxiety and depression, and influences the neuroendocrine stress response. We have recently demonstrated that prebiotics (soluble fibres that augment the growth of indigenous microbiota) have significant neurobiological effects in rats, but their action in humans has not been reported. OBJECTIVES: The present study explored the effects of two prebiotics on the secretion of the stress hormone, cortisol and emotional processing in healthy volunteers. METHODS: Forty-five healthy volunteers received one of two prebiotics (fructooligosaccharides, FOS, or Bimuno®-galactooligosaccharides, B-GOS) or a placebo (maltodextrin) daily for 3 weeks. The salivary cortisol awakening response was sampled before and after prebiotic/placebo administration. On the final day of treatment, participants completed a computerised task battery assessing the processing of emotionally salient information. RESULTS: The salivary cortisol awakening response was significantly lower after B-GOS intake compared with placebo. Participants also showed decreased attentional vigilance to negative versus positive information in a dot-probe task after B-GOS compared to placebo intake. No effects were found after the administration of FOS. CONCLUSION: The suppression of the neuroendocrine stress response and the increase in...