New Taxane Analogues from the Needles of Taxus canadensis

作者：Junzeng Zhang, Françoise Sauriol, Orval Mamer, Xiaoli You, Moulay A. Alaoui‐Jamali, Gerald Batist, Lolita O. Zamir · 发表于：Journal of Natural Products · 年份：2001 · DOI：10.1021/np0004449 · 被引用次数：17 · 研究领域：Cancer Treatment and Pharmacology、Synthetic Organic Chemistry Methods、Biological Activity of Diterpenoids and Biflavonoids

Eight minor taxanes have been identified for the first time in Taxus canadensis needles. Four of these metabolites are new taxane analogues: 7-acetyl-10-deacetyltaxol (1), 2'-acetyl-7-epi-cephalomannine (2), 10-deacetyl-10-oxo-7-epi-cephalomannine (3), and 10-acetylglycollylbaccatin VI (4).