Hair loss in a child associated with naproxen.

作者：D. Barter · 发表于：BMJ · 年份：1989 · DOI：10.1136/bmj.298.6669.325-b · 被引用次数：14 · 研究领域：Hair Growth and Disorders、Contact Dermatitis and Allergies、Nail Diseases and Treatments

shown abnormalities ranging from mild portal inflammation to centrizonal collapse with bridging.The course has been suggestive ofa hypersensitivity reaction with a shorter period to develop- ment ofabnormal liver function after re-exposure to the drug.Ours is the first case with typical pathological features of chronic active hepatitis.The evidence strongly implicated cimetidine.In- advertent re-exposure to the drug caused rapid recurrence of jaundice and abnormal liver function values, and withdrawal of cimetidine and treat- ment with prednisone for two months returned these values to normal, although repeat biopsy still showed evidence of chronic active hepatitis.Preexisting chronic active hepatitis exacerbated by cimetidine is unlikely in the absence of other recognised causes of chronic active hepatitis.This case adds to the slowly accumulating evidence implicating cimetidine as a rare but definite hepatotoxin.The low incidence makes monitoring of liver function values unlikely to be cost effective, but when clinical hepatitis occurs cimetidine must be considered a potential villain.