Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

作者：Neil I Stahl, Teri G. Boulton, Thomas J. Farruggella, Nancy Y. Ip, Sam Davis, Bruce A. Witthuhn, Frederick W. Quelle, Olli Silvennoinen, Giovanna Barbieri, Sandra Pellegrini, James N. Ihle, George D. Yancopoulos · 发表于：Science · 年份：1994 · DOI：10.1126/science.8272873 · 被引用次数：988 · 研究领域：Cytokine Signaling Pathways and Interactions、Immune Cell Function and Interaction、NF-κB Signaling Pathways

A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.