Glomerular Epithelium: Structural Alterations Induced by Polycations

作者：Seiler Mw, Manjeri A. Venkatachalam, R. S. Cotran · 发表于：Science · 年份：1975 · DOI：10.1126/science.1145209 · 被引用次数：230 · 研究领域：Caveolin-1 and cellular processes、Chronic Kidney Disease and Diabetes、Barrier Structure and Function Studies

Perfusion of rat kidneys with the polycation protamine sulfate caused glomerular epithelial alterations resembling those observed in human and experimental nephrotic states. The changes included swelling, blunting, and flattening of epithelial foot processes, were accompanied by decreased stainability of glomerular anionic sites, and were largely reversed by subsequent perfusion with the polyanion heparin.