Endemic Carbapenem Resistance Associated with OXA-40 Carbapenemase among Acinetobacter baumannii Isolates from a Hospital in Northern Spain

作者：F. Lopez-Otsoa, Lucía Gallego, Kevin J. Towner, Luke Tysall, Neil Woodford, David M. Livermore · 发表于：Journal of Clinical Microbiology · 年份：2002 · DOI：10.1128/jcm.40.12.4741-4743.2002 · 被引用次数：75 · 研究领域：Antibiotic Resistance in Bacteria、Pharmaceutical and Antibiotic Environmental Impacts、Infections and bacterial resistance

Eighty-two carbapenem-resistant isolates of Acinetobacter baumannii from a single hospital in Bilbao were typed into two major clusters and several subclusters. Disk synergy tests and PCR indicated the production of a zinc-independent OXA-class carbapenemase. Sequencing identified this enzyme, OXA-40, as a variant of the OXA-24-OXA-25-OXA-26 cluster.