Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

作者：Francis P. Kuhajda · 发表于：Nutrition · 年份：2000 · DOI：10.1016/s0899-9007(99)00266-x · 被引用次数：796 · 研究领域：Cancer, Lipids, and Metabolism、Peroxisome Proliferator-Activated Receptors、RNA modifications and cancer

This review documents the changing perspectives on the function of fatty-acid synthase and fatty-acid synthesis in human tumor biology. With the recent discovery that human cancer cells express high levels of fatty-acid synthase and undergo significant endogenous fatty-acid synthesis, our understanding of the role of fatty acids in tumor biology is expanding. Once considered largely an anabolic-energy-storage pathway, fatty-acid synthesis is now associated with clinically aggressive tumor behavior and tumor-cell growth and survival and has become a novel target pathway for chemotherapy development. These findings will ultimately enhance our understanding of fatty acids in tumor biology and may provide new diagnostic and therapeutic moieties for patient care.