Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans.

作者：Urs Ribary, Andreas A. Ioannides, Krish D. Singh, Robert G. Hasson, James Bolton, Fred Alexander Lado, Alon Y. Mogilner, Rafael H. Llinas · 发表于：Proceedings of the National Academy of Sciences · 年份：1991 · DOI：10.1073/pnas.88.24.11037 · 被引用次数：543 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、Advanced MRI Techniques and Applications

This paper introduces the use of magnetic field tomography (MFT), a noninvasive technique based on distributed source analysis of magnetoencephalography data, which makes possible the three-dimensional reconstruction of dynamic brain activity in humans. MFT has a temporal resolution better than 1 msec and a spatial accuracy of 2-5 mm at the cortical level, which deteriorates to 1-3 cm at depths of 6 cm or more. MFT is used here to visualize the origin of a spatiotemporally organized pattern of coherent 40-Hz electrical activity. This coherence, initially observed during auditory input, was proposed to be generated by recurrent corticothalamic oscillation. In support of this hypothesis, we illustrate well-defined 40-Hz coherence between cortical-subcortical sites with a time shift that is consistent with thalamocortical conduction times. Studies on Alzheimer patients indicate that, while a similar activity pattern is present, the cortical component is reduced in these subjects.