Cancer's Molecular Sweet Tooth and the Warburg Effect

作者：Jung‐whan Kim, Chi V. Dang · 发表于：Cancer Research · 年份：2006 · DOI：10.1158/0008-5472.can-06-1501 · 被引用次数：1230 · 研究领域：Cancer, Hypoxia, and Metabolism、ATP Synthase and ATPases Research、Mitochondrial Function and Pathology

More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have renewed discussions about its exact role as cause, correlate, or facilitator of cancer. Molecular advances in this area may reveal tactics to exploit the cancer cell's "sweet tooth" for cancer therapy.