A Gene Expression Map for Caenorhabditis elegans

作者：Stuart K. Kim, Jim Lund, Moni Kiraly, Kyle Duke, Min Jiang, Joshua M. Stuart, Andreas Eizinger, Brian Wylie, George S. Davidson · 发表于：Science · 年份：2001 · DOI：10.1126/science.1061603 · 被引用次数：667 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、CRISPR and Genetic Engineering、Gene Regulatory Network Analysis

We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).