The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

作者：Alan L. Schechter, Mien‐Chie Hung, Lalitha Vaidyanathan, Robert A. Weinberg, Teresa L. Yang‐Feng, Uta Francke, Axel Ullrich, Lisa M. Coussens · 发表于：Science · 年份：1985 · DOI：10.1126/science.2992090 · 被引用次数：518 · 研究领域：Neuroblastoma Research and Treatments、Cancer, Hypoxia, and Metabolism、Glycosylation and Glycoproteins Research

The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.