Sesquiterpene Alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A New Class of Potent Anti-HIV Agents

作者：Hong‐Quan Duan, Yoshihisa Takaishi, Yasuhiro Imakura, Yongfong Jia, Duan Li, L. Mark Cosentino, Kuo‐Hsiung Lee · 发表于：Journal of Natural Products · 年份：2000 · DOI：10.1021/np990281s · 被引用次数：110 · 研究领域：Natural Compounds in Disease Treatment、Natural product bioactivities and synthesis、Phytochemical compounds biological activities

Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1-5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.